Allegory of the replication crisis in algorithmic trading

One of the most interesting ongoing problems in metascience right now is the replication crisis. This a methodological crisis around the difficulty of reproducing or replicating past studies. If we cannot repeat or recreate the results of a previous study then it casts doubt on if those ‘results’ were real or just artefacts of flawed methodology, bad statistics, or publication bias. If we view science as a collection of facts or empirical truths than this…

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How I became a scientist

For the first fourteen years of my life, I thought science was boring. As far as I could tell, science was a process of memorising facts: the order of the planets, the names of clouds, the parts of a cell. Sometimes science meant building contraptions out of paper and tape to allow an egg to survive a two-metre fall, and I was really terrible at that sort of thing. So instead I spent all my…

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Process over state: Math is about proofs, not theorems.

A couple of days ago, Maylin and I went to pick blackberries along some trails near our house. We spent a number of hours doing it and eventually I turned all those berries into one half-litre jar of jam. On the way to the blackberry trails, we passed a perfectly fine Waitrose — a supermarket that sells (among countless other things) jam. A supermarket I had to go to later anyways to get jamming sugar.…

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Generating random power-law graphs

‘Power-law’ is one of the biggest buzzwords in complexology. Almost everything is a power-law. I’ve even used it to sell my own work. But most work that deals in power-laws tends to lack rigour. And just establishing that something is a power-law shouldn’t make us feel that it is more connected to something else that is a power-law. Cosma Shalizi — the great critic of sloppy thinking in complexology — has an insightful passage on…

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Blogging community of computational and mathematical oncologists

A few weeks ago, David Basanta reached out to me (and many other members of the mathematical oncology community) about building a community blog together. This week, to coincide with the Society for Mathematical Biology meeting in Montreal, we launched the blog. In keeping with the community focus, we have an editorial board of 8 people that includes (in addition to David and me): Christina Curtis, Elana Fertig, Stacey Finley, Jakob Nikolas Kather, Jacob G.…

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How does the Weddell Polynya affect Antarctic ice shelves?

The Weddell Polynya is a large hole in the sea ice of the Weddell Sea, near Antarctica. It occurs only very rarely in observations, but is extremely common in ocean models, many of which simulate a near-permanent polynya. My new paper published today in Journal of Climate finds that the Weddell Polynya increases melting beneath the nearby Filchner-Ronne Ice Shelf. This means it’s important to fix the polynya problems in ocean models, if we want…

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Closing the gap between quantum and deterministic query complexity for easy to certify total functions

Recently, trying to keep with my weekly post schedule, I’ve been a bit strapped for inspiration. As such, I’ve posted a few times on a major topic from my past life: quantum query complexity. I’ve mostly tried to describe some techniques for (lower) bounding query complexity like the negative adversary method and span programs. But I’ve never really showed how to use these methods to actually set up interesting bounds. Since I am again short…

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The gene-interaction networks of easy fitness landscapes

Since evolutionary fitness landscapes have been a recurrent theme on TheEGG, I want to return, yet again, to the question of finding local peaks in fitness landscapes. In particular, to the distinction between easy and hard fitness landscapes. Roughly, in easy landscapes, we can find local peaks quickly and in hard ones, we cannot. But this is very vague. To be a little more precise, I have to borrow the notion of orders of growth…

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Twitter vs blogs and science advertising vs discussion

I read and write a lot of science outside the traditional medium of papers. Most often on blogs, twitter, and Reddit. And these alternative media are colliding more and more with the ‘mainstream media’ of academic publishing. A particularly visible trend has been the twitter paper thread: a collection of tweets that advertise a new paper and summarize its results. I’ve even written such a thread (5-6 March) for my recent paper on how to…

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Description before prediction: evolutionary games in oncology

As I discussed towards the end of an old post on cross-validation and prediction: we don’t always want to have prediction as our primary goal, or metric of success. In fact, I think that if a discipline has not found a vocabulary for its basic terms, a grammar for combining those terms, and a framework for collecting, interpreting, and/or translating experimental practice into those terms then focusing on prediction can actually slow us down or…

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